Dr. Yoshinori Shirono, a dermatologist, launched DR.Ci:Labo in Tokyo in 1995. DR.Ci:Labo, Japan's No. 1 cosmeceutical brand, meticulously picks its ingredients, avoiding parabens, alcohol, and colorings. Following the success of its debut product, the Aqua Collagen Gel, the company launched a number of well-known goods, including the VC100 Essence Lotion and the Super100 Epidermal Growth Factor.